WELCOME TO THE LEGLEITER LAB
The major research goal of our laboratory is to understand the molecular mechanisms that underlie neurodegenerative disorders associated with protein misfolding and aggregation, with a focus on Alzheimer’s disease (AD), Huntington’s disease (HD) and Parkinson’s disease (PD). In particular, we are interested in the potential role cellular and subcellular surfaces may play in these events.
LAB NEWS
November 2011: Nicole’s poster was awarded the prize for the best poster in her category at the 22nd National NSF EPSCoR Conference, Coeur d’Alene, Idaho.
October 2011: Sam’s presentation on his research at the KY-WV LSAMP Conference was named 3rd best.
September 2011: Justin was awarded a new investigator research grant from the Alzheimer’s association: Learn more.
September 2011: Justin was interviewed on West Virginia Public Radio: “Listen here.”: http://www.wvpubcast.org/newsarticle.aspx?id=21820
September 2011: Justin was featured at halftime of the radio broadcast of the WVU vs Maryland football game: “Listen here.”: http://wvutoday.wvu.edu/resources/1/1316019450.mp3
August 2011: Congratulations to Kathleen for receiving the West Virginia University’s Women in Science and Engineering Award. Learn more.
July 2011: Michael, Sam, and Kelley presented their research at WVU’s Summer Undergraduate Research Symposium.
July 2011: Justin’s paper, “The modulating effect of mechanical changes in lipid bilayers caused by apoE-containing lipoproteins on Aβ induced membrane disruption,” was accepted by ACS Chemical Neuroscience.
MAY 2011: Justin received an NSF CAREER award to continue the group’s studies on the role of biological surfaces in Alzheimer’s disease. Learn more.
APRIL 2011: Congratulations to Elizabeth for winning the Forrest Ferrell Award.
APRIL 2011: Congratulations to Elizabeth for winning the Eberly College of Arts & Sciences Outstanding Graduate Teaching Assistant in Chemistry award.
APRIL 2011: Congratulations to Kathleen for being named an Outstanding Advanced Graduate Teaching Assistant.
APRIL 2011: Elizabeth’s paper, “Point Mutations in Aβ Induce Polymorphic Aggregates at Liquid/Solid Interfaces,” was accepted by ACS Chemical Neuroscience.
MARCH 2011: Congratulations to Kathleen for being receiving the John Conard Fellowship.
MARCH 2011: Congratulations to Elizabeth for being receiving a C. Eugene Bennett Fellowship.
JANUARY 2011: Kathleen and Jordan’s paper, “Assessing mutant huntingtin fragment and polyglutamine aggregation by atomic force microscopy,” was accepted by Methods.
DECEMBER 2010: Phil’s paper, “Point mutations in Aβ result in the formation of distinct polymorphic aggregates in the presence of lipid bilayers,” was accepted by PLoS ONE.
AUGUST 2010: Kathleen presented her research at the Hereditary Disease Foundation’s HD2010: “The Milton Wexler Celebration of Life” in Boston, MA.
MAY 2010: Congratulations to Kathleen and Elizabeth for being named the Outstanding Graduate Teaching Assistants in the Chemistry Department.
MAY 2010: Congratulations to Phil for being named the Eberly College of Arts & Sciences Outstanding Graduating Chemistry Student.
APRIL 2010: Congratulations to Elizabeth for receiving the C. Eugene Bennett Fellowship for another year.
APRIL 2010: Congratulations to Kathleen for receiving the John Conrad Fellowship for another year.
APRIL 2010: Congratulations to Phil for being named the outstanding senior Chemistry student.
APRIL 2010: Elizabeth presented her research at the Eberly College Advisory Board Dinner and Poster Presentation.
APRIL 2010: Elizabeth, Kathleen, and Kumar presented their research at the WVnano Initiative Resarch Symposium and the Eberly College of Arts and Sciences Research Horizons Day.
March 2010: Elizabeth’s poster, “Surface Effects of Mutant Aβ Aggregation”, was named second best poster in the graduate student division at the 2010 WVU Chemistry Symposium.
MARCH 2010: Justin’s paper titled “Mutant Huntingtin Fragments Form Oligomers in a Polyglutamine Length-dependent Manner In Vitro and In Vivo ” has been accepted by the Journal of Biological Chemistry. This work was performed during his postdoctoral studies in the laboratory of Dr. Paul Muchowski at the Gladstone Institute of Neurological Disease.
FEBRUARY 2010: Elizabeth and Phil present their research at the 54th Annual Biophysical Society Meeting in San Francisco.
FEBRUARY 2010: Kumar’s paper titled “The Effect of Set Point Ratio and Surface Young’s modulus on Maximum Tapping forces in Fluid tapping mode Atomic Force Microscopy” in the Journal of Applied Physics is now available on line.
JANUARY 2010: Kumar’s paper titled “The Effect of Set Point Ratio and Surface Young’s modulus on Maximum Tapping forces in Fluid tapping mode Atomic Force Microscopy” has been accepted for publication in the Journal of Applied Physics.
NOVEMBER 2009: The Legleiter lab joins the WVU Center for Neuroscience.
SEPTEMBER 2009: The Legleiter lab joins WVnano.
AUGUST 2009: Justin’s paper titled “Monoclonal antibodies recognize distinct conformational epitopes formed by polyglutamine in a mutant huntingtin fragment” has been published by the Journal of Biological Chemistry, and featured on the cover. This work was performed during his postdoctoral studies in the laboratory of Dr. Paul Muchowski at the Gladstone Institute of Neurological Disease.
MAY 2009: Justin’s paper titled “The effect of drive frequency and set-point amplitude on tapping forces in atomic force microscopy: simulation and experiment” has been published in Nanotechnology.
MAY 2009: Phil’s poster, “Disruption of lipid bilayer by β-amyloid peptide”, won best poster (undergraduate division) at the 2009 WVNano Initiative Research Symposium.
APRIL 2009: Congratulations to Elizabeth for receiving the C. Eugene Bennett Fellowship.
APRIL 2009: Congratulations to Kathleen for receiving the John Conrad Fellowship.
APRIL 2009: Phil’s poster, “Disruption of lipid bilayer by β-amyloid peptide”, won best poster at the 2009 WVU Chemistry Symposium.
